Dose-response studies with benzo[a]pyrene
نویسندگان
چکیده
منابع مشابه
Partition testing in dose-response studies with multiple endpoints.
Dose-response studies with multiple endpoints can be formulated as closed testing or partition testing problems. When the endpoints are primary and secondary, whether the order in which the doses are to be tested is pre-determined or sample determined lead to different partitioning of the parameter space corresponding to the null hypotheses to be tested. We use the case of two doses and two end...
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Dose–response studies are useful in Phase II and Phase III clinical trials to evaluate efficacy and toxicity of a drug in order to determine its effective and safe ranges. A zero dose is generally included as a control against which higher doses are compared. This naturally leads to multiple comparisons. The ordered nature of doses suggests the use of stepwise multiple test procedures. The purp...
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Most conventional risk analysis methods rely on a single best estimate of exposure per person, which does not allow for adjustment for exposure-related uncertainty. Here, we propose a Bayesian model averaging method to properly quantify the relationship between radiation dose and disease outcomes by accounting for shared and unshared uncertainty in estimated dose. Our Bayesian risk analysis met...
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BACKGROUND Two hormetic modifications of a monotonically decreasing log-logistic dose-response function are most often used to model stimulatory effects of low dosages of a toxicant in plant biology. As just one of these empirical models is yet properly parameterized to allow inference about quantities of interest, this study contributes the parameterized functions for the second hormetic model...
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ژورنال
عنوان ژورنال: Cancer
سال: 1960
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(196001/02)13:1<106::aid-cncr2820130120>3.0.co;2-n